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GHR in Cancer

Meaning

The role of GHR in Cancer refers to the significant involvement of the Growth Hormone Receptor (GHR) and its downstream signaling axis in the initiation, progression, and metastasis of various malignancies. The growth hormone/Insulin-like Growth Factor-1 (GH/IGF-1) axis is a potent mitogenic pathway, meaning it stimulates cell division and proliferation. Elevated or dysregulated GHR signaling can provide a persistent pro-survival and pro-growth signal to cancer cells, contributing to their uncontrolled replication and therapeutic resistance. Clinical and longevity research is focused on modulating this axis as a potential target for novel cancer prevention and treatment strategies.