What is the Origin of GHK-Cu Skin Revitalization?

The peptide GHK was first isolated from human plasma in 1973 by Dr. Loren Pickart, with the copper-binding form (GHK-Cu) subsequently identified as the biologically active complex. The concept of "skin revitalization" stems from decades of research demonstrating its restorative effects on dermal tissue and its profound promotion of extracellular matrix remodeling.

What is the Mechanism of GHK-Cu Skin Revitalization?

GHK-Cu acts as a critical signaling molecule that modulates the expression of numerous genes involved in tissue repair and overall skin health. It functions by forming a complex with copper ions, which are essential cofactors for lysyl oxidase, an enzyme critical for collagen cross-linking and stability. Furthermore, the peptide acts as a powerful, localized antioxidant and promotes the breakdown of abnormal collagen, collectively enhancing dermal regeneration and reducing photo-damage.

GHK-Cu Skin Revitalization ∞ Area

GHK-Cu Skin Revitalization

Meaning

GHK-Cu skin revitalization is the dermatological and aesthetic process of restoring youthful structure and function to the skin through the application or stimulation of the copper peptide Glycyl-L-Histidyl-L-Lysine-Copper (GHK-Cu). This naturally occurring human plasma peptide is widely recognized for its potent wound-healing, anti-inflammatory, and antioxidant properties. Its clinical application targets improved collagen and elastin synthesis, leading directly to enhanced skin firmness and reduced visible signs of aging.