What is the Origin of GHK-Cu Skin Rejuvenation?

The peptide GHK was first identified in human plasma in 1973 by Dr. Loren Pickart and was later found to have a high affinity for copper, forming the potent GHK-Cu complex. Its application in skin health stems from early wound healing research, where its powerful regenerative and anti-inflammatory actions were first documented. The term links the specific biochemical agent (GHK-Cu) to its clinical cosmetic outcome (skin rejuvenation).

What is the Mechanism of GHK-Cu Skin Rejuvenation?

GHK-Cu acts as a signaling peptide, modulating the expression of numerous genes involved in tissue repair and regeneration. It stimulates the production of collagen, elastin, and glycosaminoglycans, which are critical components of the extracellular matrix responsible for skin structure and hydration. Furthermore, the copper component is a necessary cofactor for the enzyme lysyl oxidase, which is vital for cross-linking collagen and elastin fibers, thus restoring the skin's tensile strength and youthful architecture.

GHK-Cu Skin Rejuvenation

Meaning

GHK-Cu skin rejuvenation refers to the use of the naturally occurring copper peptide glycyl-L-histidyl-L-lysine complexed with copper (II) to stimulate regenerative processes within the dermal layers. This tripeptide is a small, protein-like molecule that exhibits significant tissue remodeling and anti-inflammatory properties. Clinical application aims to improve skin elasticity, reduce the appearance of fine lines, and enhance overall skin barrier function. It is utilized topically and sometimes systemically for its potent effects.