What is the Origin of GHK-Cu Skin Peptide?

The peptide GHK was first isolated from human plasma in 1973 by Dr. Loren Pickart, who later identified its strong affinity for copper ions, forming the biologically active GHK-Cu complex. Its origin is endogenous, meaning it is a native component of the human body, with concentrations naturally declining with age. The therapeutic application in skin health stems from decades of research demonstrating its role as a master regulator of skin repair and regeneration.

What is the Mechanism of GHK-Cu Skin Peptide?

The mechanism of action is multifaceted: the copper-peptide complex readily penetrates the skin and acts as a carrier for copper, a crucial cofactor for the lysyl oxidase enzyme essential for collagen and elastin cross-linking. Furthermore, GHK-Cu modulates the expression of numerous genes involved in tissue repair, acts as a potent anti-inflammatory agent, and stimulates the proliferation of fibroblasts and keratinocytes. This comprehensive cellular signaling mechanism promotes the restructuring of the extracellular matrix.

GHK-Cu Skin Peptide ∞ Area

GHK-Cu Skin Peptide

Meaning

GHK-Cu Skin Peptide, chemically known as Glycyl-L-Histidyl-L-Lysine complexed with copper, is a naturally occurring human plasma peptide fragment recognized for its potent regenerative and tissue remodeling properties, particularly in dermal physiology. It functions as a key signaling molecule that modulates numerous biochemical pathways related to wound healing, collagen synthesis, and antioxidant defense. In the context of longevity aesthetics, it is utilized to enhance skin firmness, elasticity, and overall structural integrity.