What is the Origin of GHK-Cu Skin Health?

The peptide GHK was first identified in human plasma and saliva, with its copper complex (GHK-Cu) later recognized for its profound regenerative properties, particularly within the integumentary system. Its clinical relevance grew from the understanding that copper is a critical cofactor for numerous enzymes involved in collagen and elastin synthesis. The term highlights the targeted use of this specific complex for dermal optimization.

What is the Mechanism of GHK-Cu Skin Health?

GHK-Cu functions by stimulating the synthesis of collagen, elastin, and glycosaminoglycans by dermal fibroblasts, strengthening the skin's structural scaffolding. It also possesses potent antioxidant and anti-inflammatory properties, neutralizing reactive oxygen species and suppressing pro-inflammatory cytokine release. The copper ion component is essential, facilitating enzyme activity necessary for cross-linking collagen fibers and promoting angiogenesis for improved nutrient delivery.

GHK-Cu Skin Health

Meaning

GHK-Cu Skin Health refers to the utilization of the naturally occurring copper-binding tripeptide, Glycyl-L-Histidyl-L-Lysine-Copper(II), to promote dermatological integrity, repair, and aesthetic quality. This small molecule peptide is instrumental in tissue remodeling, acting as a signaling agent for extracellular matrix components. Clinical application targets the improvement of skin elasticity, reduction of photo-damage, and enhancement of wound healing.