What is the Origin of GHK-Cu Rejuvenation?

The discovery of GHK-Cu was made in the early 1970s by Dr. Loren Pickart, who identified its potent wound-healing and tissue-remodeling properties in human plasma. Its application in "Rejuvenation" stems from subsequent research demonstrating its ability to upregulate DNA repair genes, promote collagen and glycosaminoglycan synthesis, and act as a powerful antioxidant. This peptide's clinical use represents a bio-mimetic strategy to restore youthful tissue function.

What is the Mechanism of GHK-Cu Rejuvenation?

GHK-Cu functions by binding to specific receptors on cell surfaces, acting as a signaling molecule that modulates the expression of numerous genes involved in repair and regeneration. It stimulates the production of essential extracellular matrix proteins like collagen and elastin, while simultaneously scavenging reactive oxygen species and suppressing the activity of pro-inflammatory cytokines. This dual action of stimulating anabolism and reducing catabolism leads to visible improvements in skin integrity and systemic tissue health.

GHK-Cu Rejuvenation

Meaning

A targeted biological intervention utilizing the tripeptide Glycyl-L-Histidyl-L-Lysine complexed with copper (GHK-Cu) to promote tissue regeneration, anti-inflammatory effects, and enhanced wound healing. This peptide is naturally occurring in human plasma and declines significantly with age, making its external application a strategy for counteracting age-related tissue degradation. The copper component is vital for the peptide’s biological activity, especially in enzymatic reactions.