What is the Origin of GHK-Cu Peptide Mechanism?

The peptide GHK was first definitively identified in human plasma in 1973 by Dr. Loren Pickart during studies on liver cell aging. The term "GHK-Cu Peptide Mechanism" refers to the established biological actions of this molecule, where the copper ion is essential for its therapeutic function, classifying it as a copper-dependent signaling molecule.

What is the Mechanism of GHK-Cu Peptide Mechanism?

The GHK-Cu complex acts as a signaling molecule that modulates the expression of numerous genes involved in tissue repair, robust antioxidant defense, and anti-inflammatory pathways. It specifically upregulates metalloproteinases and tissue inhibitors of metalloproteinases, facilitating the necessary breakdown of damaged collagen and the synthesis of new, healthy matrix proteins. The bound copper is delivered to cells, where it serves as a critical cofactor for enzymes involved in tissue regeneration and protection against detrimental oxidative stress.

GHK-Cu Peptide Mechanism ∞ Area

GHK-Cu Peptide Mechanism

Meaning

The biological actions of Glycyl-L-Histidyl-L-Lysine-Copper (GHK-Cu), a naturally occurring human plasma copper-binding peptide that exhibits potent regenerative and protective effects across various tissues. Clinically, it is recognized for its critical role in wound healing, anti-inflammatory modulation, and stimulating the synthesis of collagen and glycosaminoglycans. This tripeptide complex is a critical component of the body’s natural tissue remodeling and repair systems.