What is the Origin of GHK-Cu Mechanism?

The peptide GHK was first isolated in 1973 from human albumin, and its strong, natural affinity for copper ions was soon established, leading to the designation GHK-Cu. Its mechanism of action has been extensively studied in the context of skin biology and wound healing, where it was recognized as a significant factor in promoting the turnover of the extracellular matrix. The understanding of its function is rooted in biochemical research into tissue repair and remodeling.

What is the Mechanism of GHK-Cu Mechanism?

GHK-Cu functions by modulating the expression of numerous genes involved in repair and regeneration, including those related to collagen and glycosaminoglycan synthesis. It acts as a signaling molecule that stimulates the breakdown of damaged collagen and elastin while promoting the synthesis of new, healthy structural components. Furthermore, its copper-dependent activity involves recruiting immune cells to the site of injury and providing potent antioxidant defense, collectively accelerating the tissue remodeling process.

GHK-Cu Mechanism

Meaning

GHK-Cu Mechanism describes the specific biological actions of the copper-binding tripeptide Glycyl-L-Histidyl-L-Lysine (GHK-Cu), a naturally occurring molecule found in human plasma. This mechanism is primarily centered on its potent tissue regeneration, anti-inflammatory, and antioxidant properties across various cell types. The presence of the copper ion is integral to its function, facilitating its role as a key signaling molecule in wound healing and the renewal of the dermal matrix. It is recognized for its restorative effects on aging skin and connective tissue.