GHK-Cu Collagen Synthesis is the biological process where the copper-peptide complex Glycyl-L-Histidyl-L-Lysine (GHK-Cu) acts as a signaling molecule to significantly upregulate the production and deposition of collagen within the extracellular matrix. This is a crucial mechanism for promoting tissue repair, enhancing skin elasticity, and strengthening connective tissues like tendons and ligaments. GHK-Cu’s influence on collagen is a key target in regenerative and aesthetic medicine.
Origin
GHK was first identified in human plasma, and its copper-binding capability led to the GHK-Cu designation. The term “collagen synthesis” is a fundamental biological concept. Its clinical relevance grew as research elucidated GHK-Cu’s potent wound healing and tissue remodeling properties.
Mechanism
GHK-Cu binds to receptors on fibroblasts and other cells, stimulating the transcription of genes responsible for collagen and elastin production. The copper ion component is essential, as copper is a required cofactor for lysyl oxidase, an enzyme that cross-links collagen fibers to provide structural strength. By enhancing this synthesis and cross-linking, GHK-Cu facilitates the orderly remodeling of damaged or aging tissue matrices.
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