What is the Origin of GHK-Cu Anti-Inflammatory?

GHK was first isolated from human plasma in the 1970s, and its affinity for copper led to the complex GHK-Cu. The 'Anti-Inflammatory' designation emerged from subsequent molecular research that characterized its gene-modulating effects beyond its initial discovery as a wound-healing agent. Its role in modulating the immune response places it as a key molecule in regenerative medicine.

What is the Mechanism of GHK-Cu Anti-Inflammatory?

The mechanism involves GHK-Cu's ability to regulate the expression of hundreds of genes, many of which are involved in inflammation and tissue repair. It actively suppresses the expression of key inflammatory mediators, such as NF-κB and various interleukins, while simultaneously upregulating anti-oxidant enzymes. By acting as a signaling molecule, GHK-Cu helps to shift the cellular environment from a pro-inflammatory, catabolic state to a regenerative, anabolic state, facilitating healing and reducing chronic tissue damage.

GHK-Cu Anti-Inflammatory ∞ Area

GHK-Cu Anti-Inflammatory

Meaning

GHK-Cu Anti-Inflammatory refers to the capacity of the copper-binding peptide Glycyl-L-Histidyl-L-Lysine (GHK-Cu) to modulate and reduce excessive inflammatory signaling within tissues. This tripeptide, naturally found in human plasma, decreases the production of pro-inflammatory cytokines and suppresses the activity of key inflammatory transcription factors. This anti-inflammatory action is crucial for tissue repair, skin health, and systemic longevity by mitigating the effects of chronic low-grade inflammation.