What is the Meaning of GHK-Cu?

GHK-Cu, or Glycyl-L-Histidyl-L-Lysine-Copper, is a naturally occurring, small-molecule peptide complex composed of the tripeptide GHK bound to a copper ion. This complex is a potent modulator of numerous physiological processes, particularly those related to tissue remodeling, wound healing, and skin health. Clinically, GHK-Cu is recognized for its ability to stimulate collagen and glycosaminoglycan synthesis, demonstrating significant anti-inflammatory and antioxidant properties within various tissue microenvironments.

What is the Origin of GHK-Cu?

The peptide GHK was first identified in human plasma in 1973 by Dr. Loren Pickart, who later determined its high affinity for copper, leading to the designation GHK-Cu. The name is a direct representation of its chemical structure: the three amino acids (Glycine, Histidine, Lysine) and the bound element (Copper). Its biological origin as an endogenous regulator of copper homeostasis and tissue repair highlights its innate role in human physiology.

What is the Mechanism of GHK-Cu?

GHK-Cu acts by forming a stable complex with copper, transporting and regulating the bioavailability of this essential trace element to cells. Once internalized, the complex modulates the expression of hundreds of human genes, often restoring the expression profiles of genes associated with tissue repair and cellular protection. Specifically, it stimulates the production of key extracellular matrix components and growth factors, while simultaneously suppressing pro-inflammatory cytokines and protecting DNA from oxidative damage, thereby facilitating a comprehensive regenerative response.

GHK-Cu ∞ Area

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