What is the Origin of GHK Copper Peptide?

Discovered in 1973 by Dr. Loren Pickart, GHK was initially isolated from human plasma and subsequently identified as a powerful modulator of tissue regeneration. Its clinical application in dermatology and cosmetology is based on its role as a natural human growth factor and metallopeptide. The term represents a convergence of biochemistry and regenerative aesthetics.

What is the Mechanism of GHK Copper Peptide?

GHK-Cu acts by binding to cellular receptors to upregulate the expression of genes involved in tissue repair, including those for collagen, elastin, and glycosaminoglycans. The copper ion delivered by the peptide is a necessary cofactor for enzymes like lysyl oxidase, which cross-links collagen, thereby strengthening the extracellular matrix. It also possesses strong anti-inflammatory and antioxidant capabilities, protecting cells from damage.

GHK Copper Peptide ∞ Area

GHK Copper Peptide

Meaning

GHK Copper Peptide is a naturally occurring tripeptide, Glycyl-L-Histidyl-L-Lysine, that forms a stable complex with a copper ion, denoted as GHK-Cu. This small signaling molecule is recognized for its potent regenerative and protective properties across multiple tissues, particularly the skin, hair, and liver. It functions as a key component in wound healing and tissue remodeling processes.