What is the Origin of GH Side Effects?

The documentation of GH side effects emerged with the advent of recombinant human growth hormone (rhGH) therapy, allowing for widespread clinical use in both pediatric and adult GH deficiency. Initial observations of side effect profiles in the 1980s and 1990s led to refinement of dosing strategies and contraindications in endocrinology.

What is the Mechanism of GH Side Effects?

Many side effects are dose-dependent and result from GH's pleiotropic actions mediated primarily through Insulin-like Growth Factor 1 (IGF-1). Fluid retention and edema occur due to GH's anti-natriuretic effect, causing increased renal reabsorption of sodium and water. Arthralgia and carpal tunnel syndrome are often attributed to the proliferation of connective tissue and fluid accumulation within confined spaces, secondary to elevated IGF-1 signaling.

GH Side Effects ∞ Area

GH Side Effects

Meaning

Undesirable physiological reactions that can occur during therapeutic administration of Growth Hormone (GH), particularly when dosages are supraphysiological or not adequately monitored. Common adverse events include peripheral edema, arthralgia (joint pain), carpal tunnel syndrome, and potential alterations in glucose metabolism leading to insulin resistance. Careful clinical titration is necessary to mitigate these risks.