Question 1

What is the Meaning of GH Sensitivity?

Accepted Answer

GH Sensitivity refers to the degree of biological responsiveness exhibited by target tissues, most notably the liver, to the circulating concentration of Growth Hormone (GH) secreted by the anterior pituitary gland. This sensitivity is a critical determinant of the overall functional status of the somatotropic axis, influencing the downstream production of Insulin-like Growth Factor-1 (IGF-1). Adequate GH sensitivity is essential for maintaining anabolic processes, regulating body composition, and supporting metabolic health throughout the lifespan. Clinical assessment of this parameter is often more informative than simply measuring basal GH levels, which are pulsatile in nature.

Question 2

What is the Origin of GH Sensitivity?

Accepted Answer

The term is rooted in classical endocrinology and the discovery of the Growth Hormone-Insulin-like Growth Factor-1 (GH-IGF-1) axis, which emerged from the early 20th-century understanding of growth regulation. The concept of "sensitivity" became paramount with the recognition of conditions like Laron syndrome, where GH levels are high but tissue response is absent due to receptor defects. The physiological origin lies in the cell's requirement for functional GH receptors (GHR) to transduce the hormonal signal into a biological effect.

Question 3

What is the Mechanism of GH Sensitivity?

Accepted Answer

The molecular mechanism is initiated when Growth Hormone binds to the Growth Hormone Receptor (GHR) on the surface of target cells, primarily hepatocytes in the liver. This binding induces the dimerization of the receptor, which then activates an associated intracellular tyrosine kinase, Janus Kinase 2 (JAK2). JAK2 subsequently phosphorylates downstream signaling molecules, notably the Signal Transducer and Activator of Transcription (STAT) proteins, which translocate to the nucleus to induce the transcription of the IGF-1 gene. Therefore, GH sensitivity is mechanistically defined by the efficiency of this GHR-JAK2-STAT signaling cascade.

GH Sensitivity

Meaning

Origin

Mechanism

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