What is the Origin of GH Releasing Peptides?

These peptides, such as GHRP-6 or Ipamorelin, were developed through extensive research into the hypothalamic regulation of the somatotropic axis. Their origin lies in understanding the GHS (Growth Hormone Secretagogue) receptor system, distinct from the GH-releasing hormone pathway.

What is the Mechanism of GH Releasing Peptides?

The primary mechanism involves direct binding to the GHS receptor located on pituitary somatotrophs, triggering a calcium-dependent cascade that results in the exocytosis of pre-formed GH vesicles. This action overrides the negative feedback exerted by somatostatin, leading to a significant, yet often physiological, spike in circulating GH and subsequent IGF-1 elevation.

GH Releasing Peptides

Meaning

GH Releasing Peptides are synthetic or natural oligopeptides designed to stimulate the pulsatile release of endogenous Growth Hormone (GH) from the anterior pituitary gland. These compounds act as secretagogues, effectively bypassing normal somatostatin inhibition to promote anabolic signaling. They are utilized clinically to improve body composition and tissue repair capacity.