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GH Receptor

Meaning

The GH receptor, or Growth Hormone receptor, is a transmembrane protein expressed on the surface of numerous cell types, particularly hepatocytes, which mediates the biological actions of Growth Hormone (GH). Upon binding its ligand, the receptor dimerizes and initiates an intracellular signaling cascade, most notably through the JAK-STAT pathway, which ultimately leads to the transcription of genes responsible for growth and metabolic regulation. The receptor’s function is central to somatic growth, body composition, and overall metabolic health, including the regulation of Insulin-like Growth Factor 1 (IGF-1) synthesis. Deficiencies or resistance at the receptor level can lead to significant clinical syndromes.