What is the Origin of GGT?

GGT stands for Gamma-Glutamyl Transferase, an enzyme named for its specific biochemical function of transferring a gamma-glutamyl group. Its clinical utility was established in the mid-20th century as a key diagnostic tool in hepatology. The measurement of this enzyme in blood provides a window into cellular integrity and detoxification capacity.

What is the Mechanism of GGT?

GGT plays a crucial role in the gamma-glutamyl cycle, which is the primary pathway for the synthesis and degradation of glutathione, the body's most important endogenous antioxidant. When liver cells are damaged or bile flow is obstructed, GGT is released into the bloodstream, causing serum levels to rise. This elevation reflects a compromise in the cellular machinery responsible for managing oxidative load and maintaining detoxification.

GGT ∞ Area

GGT

Meaning

GGT is the acronym for Gamma-Glutamyl Transferase, an enzyme predominantly localized on the cell membranes of hepatocytes, renal tubules, and pancreatic cells. In clinical diagnostics, serum GGT is a highly sensitive, though non-specific, marker used to assess hepatobiliary function and is often an indicator of liver stress, including damage from oxidative stress or excessive alcohol intake. Elevated levels warrant further investigation into liver and metabolic health.