What is the Origin of Geroscience Therapeutic Targets?

The term is derived directly from the interdisciplinary field of Geroscience, which connects the basic biology of aging with the biology of age-related diseases. The core hypothesis is that targeting the mechanisms of aging itself will prevent or delay multiple chronic conditions simultaneously, offering a higher leverage point for intervention. This approach shifts the clinical focus from treating individual diseases to optimizing fundamental longevity pathways.

What is the Mechanism of Geroscience Therapeutic Targets?

The therapeutic mechanism involves using pharmacological agents, peptides, or lifestyle interventions to modulate these core aging pathways. Examples include activating sirtuins, clearing senescent cells via senolytics, or improving nutrient sensing pathways like mTOR and AMPK to regulate cellular energy. The function is to restore youthful cellular processes, enhance DNA repair mechanisms, and improve systemic resilience, thereby extending the duration of healthy, high-functioning life.

Geroscience Therapeutic Targets ∞ Area

Geroscience Therapeutic Targets

Meaning

Geroscience Therapeutic Targets are specific molecular, cellular, and systemic pathways identified by longevity research as fundamental drivers of the aging process and age-related disease. Clinically, these targets—such as cellular senescence, mitochondrial dysfunction, and chronic inflammation—represent actionable points for intervention to slow biological aging and compress the period of morbidity. Focusing on these targets allows for a proactive, disease-agnostic approach to healthspan extension.