What is the Origin of Geroscience Protocols?

The term Geroscience Protocols is a direct evolution from the Geroscience Hypothesis, which posits that intervening in the aging process itself will prevent or delay the onset of the entire cluster of age-related diseases. This field emerged from molecular biology and genetics, identifying conserved pathways that govern longevity across species. The protocols represent the clinical translation of this hypothesis, moving the science from the laboratory into structured, human-centered interventions.

What is the Mechanism of Geroscience Protocols?

The protocols mechanistically function by modulating key longevity pathways, including the nutrient-sensing systems like mTOR, AMPK, and the Sirtuins, which govern cellular stress response and repair. They often incorporate strategies to induce autophagy, clear senescent cells using senolytics, and restore the integrity of the genome and epigenome. Hormonal optimization is frequently a core component, as endocrine signals act as master switches for many of the metabolic and regenerative pathways targeted by geroscience.

Geroscience Protocols

Meaning

Geroscience Protocols are structured, evidence-based clinical strategies derived from the scientific field of geroscience, which specifically targets the fundamental biological processes of aging rather than just treating individual age-related diseases. These protocols integrate pharmacological agents, targeted nutritional interventions, and specific lifestyle modifications designed to modulate the hallmarks of aging, such as cellular senescence and mitochondrial dysfunction. The ultimate goal is to extend healthspan by slowing the rate of biological decline and reducing the risk of multiple chronic conditions simultaneously.