What is the Origin of Geroscience Hypothesis?

This hypothesis emerged from the convergence of gerontology and basic biomedical science, formalizing the idea that aging itself is a modifiable process. The term "geroscience" combines the Greek geron (old man) and "science," representing a dedicated field of study focused on the biology of aging. It provides a new framework for clinical longevity interventions.

What is the Mechanism of Geroscience Hypothesis?

The core mechanism involves targeting the nine proposed hallmarks of aging, which include genomic instability, telomere attrition, and altered intercellular communication. By therapeutically modulating these fundamental processes, geroscience aims to maintain youthful cellular function and systemic resilience. For example, clearing senescent cells can reduce chronic inflammation, thereby protecting the endocrine system from age-related dysfunction.

Geroscience Hypothesis ∞ Area

Geroscience Hypothesis

Meaning

A unifying scientific concept positing that the fundamental biological processes of aging are the primary risk factors for chronic diseases, rather than these diseases being separate, independent entities. The hypothesis suggests that intervening in the core mechanisms of aging, such as cellular senescence and mitochondrial dysfunction, can simultaneously prevent or delay the onset of multiple age-related conditions, including hormonal decline. This perspective shifts the clinical focus from disease management to healthspan extension.