The application of research findings from the biology of aging to specifically preserve, maintain, or enhance neurocognitive function throughout later life stages. This focus targets the molecular drivers of brain aging to preserve intellect. It is a proactive strategy against age-related cognitive slowing.
Origin
This term fuses the broad discipline of geroscience—the study of aging mechanisms—with the specific clinical goal of cognitive longevity. It recognizes that cognitive decline is not inevitable but is influenced by fundamental aging processes.
Mechanism
Strategies often involve mitigating age-related cellular insults such as chronic oxidative stress and impaired proteostasis within neurons. Supporting cerebral vascular health is also key, ensuring adequate delivery of oxygen and substrates. Furthermore, optimizing systemic hormonal milieu supports the necessary neurotrophic support for synaptic maintenance.
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