What is the Origin of Geroscience Diet Principles?

This dietary philosophy is rooted in Geroscience, an interdisciplinary field that seeks to understand the link between aging and age-related diseases. Key concepts emerged from decades of research into caloric restriction, intermittent fasting, and the role of nutrient-sensing pathways like mTOR and AMPK in regulating lifespan. It represents the direct application of molecular aging research to clinical nutrition and hormonal health.

What is the Mechanism of Geroscience Diet Principles?

The diet is engineered to periodically or chronically induce mild metabolic stress signals that activate cellular defense and repair mechanisms, mimicking the effects of caloric restriction. This includes optimizing macronutrient ratios to manage insulin sensitivity, utilizing fasting windows to promote autophagy, and incorporating senolytic or anti-inflammatory compounds. By influencing nutrient sensing and cellular stress response, these principles aim to maintain youthful hormonal signaling and tissue function.

Geroscience Diet Principles ∞ Area

Geroscience Diet Principles

Meaning

Geroscience Diet Principles are nutritional strategies specifically designed to target the fundamental biological mechanisms of aging, known as the hallmarks of aging. These principles extend beyond general healthy eating by focusing on dietary patterns and specific compounds that modulate cellular processes linked to longevity, such as nutrient sensing pathways and cellular senescence. The goal is to extend healthspan by actively slowing the biological aging process at the molecular level.