Skip to main content

Germline Transmission

Meaning

Germline transmission is the biological process by which genetic and, importantly, epigenetic information is faithfully passed down from a parent to their offspring via the gametes—the sperm and the egg. This transmission ensures the continuity of the species but also carries the potential for inherited predispositions to certain health conditions, even those not encoded in the primary DNA sequence. It represents the crucial biological link that connects parental health status, including hormonal and environmental exposures, to the developmental trajectory and future health of the progeny. The integrity of the germline is paramount for reproductive health and generational wellness.