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Genomic Signaling Pathways

Meaning

Genomic signaling pathways are the complex, multi-step cascades of molecular interactions that ultimately transmit external and internal signals, such as hormones or nutrient status, to the cell nucleus to modulate gene expression. These pathways involve a series of protein activations that result in the binding of transcription factors to specific DNA sequences, thereby controlling the synthesis of new proteins. This fundamental process is the cellular mechanism by which the endocrine system exerts its long-term effects on growth, metabolism, and adaptation. Dysregulation in these pathways underlies many age-related and hormonal disorders.