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Genomic Pathway Activation

Meaning

Genomic Pathway Activation refers to the specific process where a lipophilic signaling molecule, typically a steroid hormone, binds to its intracellular receptor, and the resulting hormone-receptor complex subsequently translocates to the nucleus to directly influence gene transcription. This crucial activation leads to the synthesis of new messenger RNA and the subsequent production of specific proteins, fundamentally altering the long-term functional and structural characteristics of the target cell. It represents the slower, yet more sustained and profound, mode of hormonal action within the entire endocrine system.