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Genomic Instability

Meaning

Genomic Instability is a profound cellular state characterized by an abnormally high rate of structural or numerical alterations in the cell’s chromosomal DNA, resulting in a compromised integrity of the entire genome. This fundamental defect is recognized as a primary hallmark of both the aging process and the initial driving force behind oncogenesis and various other degenerative pathologies. Maintaining the stability of the genome is absolutely essential for accurate cellular replication and the faithful preservation of genetic information across generations.