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Genomic Hormone Pathways

Meaning

Genomic Hormone Pathways describe the intricate sequence of molecular events where steroid and thyroid hormones exert their influence by directly modulating gene expression within the cell nucleus. These pathways involve the hormone binding to specific intracellular receptors, forming a ligand-receptor complex that subsequently translocates to the DNA to bind to hormone response elements (HREs). This direct interaction fundamentally alters the transcription rate of target genes, leading to changes in the synthesis of specific proteins and ultimately regulating a vast array of physiological functions. This is a central mechanism for long-term hormonal control over metabolism, development, and mood.