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Genomic Effects of Testosterone

Meaning

The Genomic Effects of Testosterone describe the actions of the steroid hormone that involve direct binding to intracellular androgen receptors (AR) and subsequent modulation of gene transcription within the cell nucleus. This classic endocrine signaling pathway results in the synthesis of new proteins, leading to long-term physiological changes in target tissues. These effects are crucial for male sexual differentiation, the development of secondary sexual characteristics, maintenance of bone density, and regulation of muscle mass and hematopoiesis. Understanding this mechanism is fundamental to the clinical use of androgen replacement therapy.