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Genomic Effects

Meaning

Genomic effects describe the biological consequences that result from a substance, such as a steroid hormone, directly interacting with the cell’s nuclear DNA to modulate gene transcription and subsequent protein synthesis. These effects typically involve the hormone binding to an intracellular receptor, forming a complex that translocates to the nucleus and acts as a transcription factor, thereby altering the expression profile of specific genes. Genomic signaling pathways are responsible for the long-term, profound physiological changes mediated by steroid hormones.