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Genomic Crosstalk

Meaning

Genomic crosstalk describes the complex, bidirectional regulatory interactions between different genetic elements, signaling pathways, and the systemic endocrine system, where the activity of one gene or pathway profoundly influences the expression and function of others. In hormonal health, this refers to how hormone-receptor binding influences gene expression, and how, in turn, specific genetic variants modulate hormone synthesis, metabolism, and target-tissue receptor sensitivity. It highlights the profound, intricate interconnectedness of the entire genome and the endocrine regulatory network.