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Genetic Sleep Disorders

Meaning

Genetic Sleep Disorders are a category of sleep-wake abnormalities whose etiology is directly linked to mutations or polymorphisms in specific genes, often those regulating the circadian rhythm or sleep homeostasis. These conditions, such as Familial Advanced Sleep Phase Syndrome, Familial Natural Short Sleep, or certain forms of narcolepsy, manifest as profound, often lifelong disturbances in sleep timing, duration, or quality that are largely refractory to conventional environmental interventions alone. Identifying the underlying genetic signature is essential for accurate diagnosis, genetic counseling, and the development of highly targeted, personalized therapeutic strategies. The recognition of these disorders underscores the critical role of genomics in the regulation of sleep.