The extent to which an individual’s realized physical and metabolic characteristics align with the optimal functional expression dictated by their inherited genetic blueprint. This is not about achieving a theoretical maximum, but about closing the gap between inherent potential and current biological reality, often constrained by epigenetic factors. We seek to unlock inherent capacity.
Origin
‘Genetic’ refers to inherited traits, ‘potential’ to the ceiling of capability, and ‘realization’ to the act of achieving that state. In endocrinology, this concept addresses how environmental and lifestyle inputs either permit or inhibit the expression of genes coding for optimal receptor function or hormone synthesis machinery. It is a concept rooted in developmental biology and personalized response.
Mechanism
Realization is mediated by epigenetic modifiers that influence gene transcription rates for key enzymes, transporters, and hormone receptors. For example, optimal thyroid hormone action requires adequate nutrient cofactors to ensure proper nuclear receptor binding and downstream gene activation. Stress exposure or chronic inflammation can epigenetically silence pathways necessary for full genetic expression.
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