Genetic Level Aging refers to the cumulative, measurable molecular damage and functional decline that occurs within the cell’s genetic material and its associated regulatory machinery over time. Key markers of this fundamental process include the progressive shortening of telomeres, the accumulation of somatic mutations in DNA, and adverse epigenetic modifications that alter gene expression. This is considered one of the core, primary hallmarks of biological aging, directly influencing cellular senescence and the systemic decline in hormonal production and receptor function. It provides a precise molecular target for longevity interventions.
Origin
This term is a conceptualization arising from modern gerontology and molecular biology, combining “genetic level,” referring to the scale of DNA and chromosomes, with “aging,” the process of decline over time. The scientific foundation lies in the discovery of specific molecular mechanisms, such as telomerase activity and DNA repair pathways, that govern cellular lifespan. It provides a molecular lens for understanding the root causes of age-related physiological changes.
Mechanism
The mechanism centers on the progressive erosion of the protective telomeric caps on chromosomes with each cell division, eventually signaling the cell to enter replicative senescence. Simultaneously, reactive oxygen species and metabolic byproducts cause cumulative DNA damage, which can overwhelm the cell’s intrinsic repair capacity. These events, combined with dysregulated epigenetic marks, collectively impair the accurate expression of genes critical for maintaining youthful hormonal signaling and cellular homeostasis.
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