A therapeutic or lifestyle strategy aimed at systematically adjusting the rate at which specific genes are transcribed into functional proteins, effectively modifying the body’s molecular output. This process does not alter the underlying DNA sequence but focuses on epigenetic mechanisms to optimize the production of beneficial hormones, enzymes, and cellular components. Recalibration seeks to move gene expression patterns toward a more youthful or robust physiological state.
Origin
The concept arises from the field of epigenetics, which demonstrated that environmental and nutritional factors can profoundly influence gene expression without changing the core genetic code. The term “Recalibration” emphasizes a deliberate, targeted clinical effort to restore a desirable, balanced pattern of genetic activity that may have been compromised by age or environmental stress.
Mechanism
Recalibration is typically achieved through the precise use of nutritional factors, specific hormonal modulators, or targeted lifestyle interventions that influence DNA methylation and histone modification. These epigenetic shifts alter the accessibility of genes to the transcription machinery, thereby increasing the expression of genes associated with cellular repair and longevity while silencing those linked to inflammatory or senescent pathways.
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