A targeted clinical approach utilizing specific environmental, nutritional, and therapeutic interventions to favorably influence the transcription of genes associated with health, longevity, and optimal physiological function. This strategy does not alter the underlying DNA sequence but modifies epigenetic markers and signaling pathways to ensure beneficial genes are actively expressed, while detrimental or pro-aging genes are suppressed. It represents the application of nutrigenomics and epigenetics in clinical practice.
Origin
The term is rooted in the field of molecular biology and epigenetics, which demonstrated that gene activity is highly plastic and responsive to environmental input, not solely determined by genetics. The concept of “priming” refers to preparing the cellular environment for an optimal response to stimuli, effectively leveraging genetic predispositions for better health outcomes. This is a foundational element of advanced precision medicine.
Mechanism
Priming functions by introducing specific bioactive compounds, such as certain vitamins, minerals, or peptide signals, that act as cofactors or ligands for transcription factors, directly or indirectly modulating gene promoters. For instance, specific interventions can enhance the expression of sirtuins or FOXO transcription factors, which are critical for cellular stress resistance and DNA repair. The underlying mechanism is the optimization of the cellular signaling cascade that controls which genetic instructions are read and executed.
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