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Gene-Sex Interaction

Meaning

Gene-Sex Interaction refers to the differential effect that an individual’s biological sex, which is determined by sex chromosomes and gonadal hormones, has on the expression, penetrance, or functional outcome of specific genes. This interaction signifies that the same genetic variant may manifest a distinct physiological or pathological phenotype in males compared to females, particularly in hormone-sensitive tissues. Recognizing this fundamental biological difference is crucial for developing precision medicine and sex-specific therapeutic protocols in hormonal health.