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Gene Polymorphisms

Meaning

Gene polymorphisms refer to common variations in the DNA sequence at a specific location, or locus, that occur in a significant portion of the population, often defined as greater than one percent. These single nucleotide changes, or single nucleotide polymorphisms (SNPs), are distinct from rare mutations and contribute to the vast genetic diversity among individuals. In hormonal health, polymorphisms can influence enzyme activity, receptor sensitivity, and hormone metabolism, impacting an individual’s response to environmental factors or therapeutic interventions. Understanding these variations is fundamental to the practice of personalized medicine.