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Gene-By-Hormone Interaction

Meaning

Gene-By-Hormone Interaction describes the intricate, reciprocal relationship where an individual’s specific genetic variations influence the body’s response to hormones, and conversely, where hormonal signaling affects gene expression and function. This critical concept explains why patients exhibit heterogeneous responses to the same hormone replacement therapy or why genetic polymorphisms in hormone receptor genes alter metabolic outcomes. Understanding these interactions is fundamental to the practice of personalized endocrinology, allowing clinicians to tailor therapeutic dosages and choices based on an individual’s unique genomic blueprint. This biological crosstalk dictates many aspects of human physiology, from pubertal development to the risk of hormone-sensitive malignancies.