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GCKR

Meaning

GCKR is the acronym for Glucokinase Regulatory Protein, a highly significant protein encoded by the GCKR gene that acts as a pivotal regulator of glucose metabolism, primarily within the liver and pancreas. This protein functions as an inhibitory binding partner for the enzyme glucokinase, which serves as the body’s key glucose sensor and the rate-limiting enzyme for glucose utilization in these tissues. Genetic polymorphisms in the GCKR gene are clinically associated with significant variations in both glucose and lipid homeostasis.