Question 1

What is the Meaning of GC-MS/MS?

Accepted Answer

GC-MS/MS, or Gas Chromatography-Tandem Mass Spectrometry, is a highly sensitive and selective analytical technique used in clinical and research laboratories to identify and quantify specific compounds, including steroid hormones and their metabolites, within biological samples. This method offers superior specificity and lower detection limits compared to single mass spectrometry. It is considered the gold standard for accurate, unambiguous hormonal profiling and metabolite quantification.

Question 2

What is the Origin of GC-MS/MS?

Accepted Answer

The term is an acronym representing the sequential combination of two distinct analytical technologies. Gas Chromatography (GC) was developed in the mid-20th century for separating complex mixtures, and Mass Spectrometry (MS) for identifying compounds. The tandem (MS/MS) configuration represents an advanced evolution, allowing for an extra layer of structural confirmation and significantly reduced matrix interference.

Question 3

What is the Mechanism of GC-MS/MS?

Accepted Answer

The sample is first separated into its constituent compounds by the Gas Chromatograph based on volatility and affinity for the column material. These separated compounds then enter the first Mass Spectrometer (MS1), which fragments them into characteristic ions. The second Mass Spectrometer (MS2) selects and analyzes only the specific fragments of interest, providing a unique molecular fingerprint. This dual-stage mass analysis ensures the precise and unambiguous quantification of targeted hormonal analytes, even at very low concentrations.

GC-MS/MS

Meaning

Origin

Mechanism

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