What is the Origin of Gastric Protective Peptides?

The discovery of these peptides is rooted in the field of gastrointestinal endocrinology, where researchers identified various gut-brain axis hormones that influence digestive function and mucosal defense. The term emphasizes the protective, rather than purely digestive or absorptive, function of these small proteins. Examples include trefoil peptides and specific growth factors secreted locally within the gut.

What is the Mechanism of Gastric Protective Peptides?

The protective mechanism involves paracrine and endocrine signaling, where peptides act on local gastric and duodenal cells to enhance the mucosal barrier. They promote angiogenesis, increasing local blood supply to facilitate rapid repair, and stimulate the secretion of a protective layer of mucus and bicarbonate ions. This concerted biochemical action maintains the delicate balance between aggressive luminal factors and the integrity of the gastric epithelium.

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Gastric Protective Peptides

Meaning

Gastric protective peptides are a group of endogenous signaling molecules that play a vital role in safeguarding the mucosal lining of the stomach and upper gastrointestinal tract from damage caused by gastric acid, digestive enzymes, and external stressors. These peptides contribute to mucosal integrity by promoting blood flow, stimulating mucus and bicarbonate secretion, and inhibiting acid production. They are essential for preventing conditions like peptic ulcers and gastritis.