What is the Origin of Gastric Peptides?

The term originates directly from the fields of gastroenterology and endocrinology, combining the Greek word gaster (stomach) with the biochemical term peptide (a chain of amino acids). Their discovery was central to understanding the gut-brain axis, revealing how the digestive system communicates its status to the central nervous system and other peripheral organs to coordinate energy balance.

What is the Mechanism of Gastric Peptides?

These peptides act as hormones or paracrine messengers, binding to specific G-protein coupled receptors (GPCRs) located on target cells within the gut, pancreas, liver, and hypothalamus. For instance, Ghrelin binds to the Growth Hormone Secretagogue Receptor (GHSR) in the hypothalamus to stimulate appetite and growth hormone release. The coordinated action of gastric peptides ensures nutrient absorption is optimized while simultaneously controlling energy intake and expenditure, which is vital for metabolic health.

Gastric Peptides ∞ Area

Gastric Peptides

Meaning

Gastric Peptides are a diverse group of short-chain amino acid compounds secreted primarily by the stomach and upper gastrointestinal tract, functioning as key signaling molecules in the neuroendocrine system. These peptides are essential for regulating appetite, satiety, gastric motility, and the secretion of digestive enzymes and acids. Clinically relevant examples include Ghrelin, which stimulates hunger, and Gastrin, which promotes gastric acid secretion.