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Gap Junctions

Meaning

Gap junctions are specialized intercellular channels that directly connect the cytoplasm of two adjacent cells, forming a critical conduit for the rapid, direct passage of ions, small molecules, and signaling metabolites. These protein structures are essential for electrical and metabolic coupling, enabling synchronized activity across a tissue, such as coordinated contraction in the heart or synchronous hormone release in endocrine glands. In the context of hormonal health, their function is critical for tissue homeostasis and the coordinated, rapid response of cell populations to systemic endocrine signals. They represent a fundamental and direct mode of cell-to-cell communication.