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Gamma-Glutamyl Transferase

Meaning

Gamma-Glutamyl Transferase, commonly abbreviated as GGT, is an enzyme that is predominantly concentrated in the liver, bile ducts, and kidneys, though it is present in other tissues as well. This enzyme plays a crucial role in the cellular metabolism of glutathione, the body’s primary endogenous antioxidant, and facilitates the transport of amino acids across cell membranes. Clinically, elevated serum GGT levels are a sensitive, though non-specific, indicator of liver or bile duct dysfunction, often signaling exposure to hepatotoxic agents or chronic alcohol consumption.