What is the Origin of Galectin-3?

The name derives from its conserved carbohydrate recognition domain (Galectin family) and its affinity for specific galactose residues. Its identification stemmed from early molecular biology studies on cell surface glycoproteins. In a systemic context, its relevance has expanded into cardiovascular and renal pathology.

What is the Mechanism of Galectin-3?

Extracellularly, Galectin-3 can modulate inflammatory cell recruitment and promote fibrotic remodeling in response to injury or chronic stress. High levels often correlate with increased systemic burden, potentially interacting with metabolic pathways that affect insulin sensitivity. While not a classical hormone, its signaling influence reflects underlying tissue perturbation that impacts overall endocrine function.

Galectin-3

Meaning

Galectin-3 is a carbohydrate-binding protein, or lectin, found both intracellularly and extracellularly, which plays roles in cell-cell adhesion, signaling, and inflammatory processes. Elevated circulating levels are often utilized as a biomarker reflecting underlying tissue stress or fibrosis development. This protein is involved in complex interactions within the extracellular matrix.