Skip to main content

GABAergic Tone

Meaning

GABAergic tone refers to the baseline, continuous level of inhibitory neurotransmission mediated by Gamma-aminobutyric acid (GABA), which is the principal inhibitory neurotransmitter operating within the central nervous system. This persistent inhibitory influence is essential for precisely regulating overall neuronal excitability, modulating anxiety levels, and promoting the consolidation of restful sleep architecture. A well-maintained GABAergic tone is crucial for neurological homeostasis, cognitive function, and systemic psychological well-being, especially in its interaction with the endocrine axes.