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GABAergic System

Meaning

The GABAergic System refers to the entire network of neural structures, receptors, and enzymes that utilize gamma-aminobutyric acid (GABA) as the principal inhibitory neurotransmitter in the central nervous system (CNS). This system is crucial for regulating neuronal excitability, promoting calmness, reducing anxiety, and facilitating sleep, thereby exerting a profound influence on mood and cognitive function. Within hormonal health, the GABAergic system interacts significantly with neurosteroids, which can act as positive allosteric modulators to enhance its inhibitory effects. A well-functioning GABAergic system is vital for maintaining neuroendocrine resilience and managing stress responses.