GABAergic System Calm describes the state of physiological tranquility and reduced neuronal excitability achieved through the optimal function of the Gamma-Aminobutyric Acid (GABA) neurotransmitter system. GABA is the primary inhibitory neurotransmitter in the central nervous system, responsible for counteracting the excitatory signals of glutamate to promote relaxation, alleviate anxiety, and facilitate sleep onset. Clinical strategies aim to support this system to induce a natural, non-sedating sense of calm and to restore balance to an overstimulated nervous system.
Origin
The concept originates from neurochemistry, following the discovery and characterization of GABA as a key amino acid neurotransmitter in the mid-20th century. The term “GABAergic” specifically refers to the neurons and synapses that use GABA. The pairing with “Calm” reflects the recognized clinical outcome of modulating this system, which is a fundamental principle in psychopharmacology and nutritional psychiatry.
Mechanism
GABA exerts its inhibitory effect by binding to specific GABA receptors, most notably the GABA-A receptor, which is a ligand-gated ion channel. This binding causes an influx of chloride ions into the neuron, leading to hyperpolarization of the cell membrane. This change makes the neuron less likely to fire an action potential, effectively dampening neural activity and reducing the overall level of central nervous system arousal. Adequate support for GABA synthesis and receptor sensitivity is crucial for maintaining emotional and physiological stability.
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