What is the Origin of GABAergic Inhibition?

The name is derived from the chemical structure of GABA, Gamma-Aminobutyric Acid, and the process of inhibition, meaning the reduction of neuronal firing rate. This inhibitory control is vital for preventing excitotoxicity and regulating the output of various brain centers.

What is the Mechanism of GABAergic Inhibition?

When GABA binds to GABA-A receptors, it facilitates the influx of negatively charged chloride ions into the postsynaptic neuron. This influx hyperpolarizes the cell membrane, moving the electrical potential further away from the threshold required to fire an action potential. Consequently, GABAergic inhibition effectively quiets neural circuits that might otherwise overstimulate downstream processes, including neuroendocrine release centers.

GABAergic Inhibition

Meaning

GABAergic Inhibition describes the primary mechanism of neuronal dampening within the central nervous system mediated by the neurotransmitter Gamma-Aminobutyric Acid (GABA) acting upon its cognate receptors. This process is essential for balancing neural excitation and maintaining appropriate signaling thresholds.

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