A proactive, comprehensive strategy aimed at optimizing the long-term structural and functional integrity of the brain to mitigate the risk of age-related cognitive decline and neurodegenerative diseases. This involves the deliberate application of evidence-based lifestyle, nutritional, and clinical interventions to build cognitive reserve and enhance neural resilience. It is an aspirational term for maximal neurological longevity.
Origin
This phrase is a modern, consumer-facing distillation of principles derived from gerontology, cognitive neuroscience, and preventive medicine, translating complex research into a practical wellness goal. The concept emphasizes a shift from passive aging to active neuro-optimization, recognizing the brain’s plasticity throughout life. It is closely linked to the growing fields of personalized longevity and bio-optimization.
Mechanism
The strategy operates by modulating core biological processes that underpin neurodegeneration, including reducing chronic systemic inflammation, optimizing cerebral blood flow, and balancing neurohormonal profiles. Key interventions aim to enhance neuroplasticity through factors like brain-derived neurotrophic factor (BDNF) and support mitochondrial function in neurons. The goal is to sustain robust synaptic health and maintain efficient neural network connectivity over many decades.
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